LC-MS/MS Method for the Quantitative Determination of Tanespimycin and its Active Metabolite in Human Plasma: Method Validation and Overcoming an Insidious APCI Source Phenomenon

LC-MS/MS Method for the Quantitative Determination of Tanespimycin and its Active Metabolite in Human Plasma: Method Validation and Overcoming an Insidious APCI Source Phenomenon

OBJECTIVES: To develop a LC-MS/MS method for simultaneous measurement of Tanespimycin (17-(allylamino)-17-demethoxygeldanamycin, BMS-722782, 17-AAG) and its active metabolite 17-(amino)-17-demethoxygeldanamycin (17-AG) in human plasma. METHODS: The samples were extracted by protein precipitation...

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Bibliographic Details
Main Authors: Morse Faria, Omnia A. Ismaiel, James Waltrip, Tom Mariannino, Moucun Yuan, William Mylott, Vikram Roongta, Jim X. Shen, Pathanjali Kadiya
Format: Article
Language:English
Published: Betasciencepress Publishers 2020-08-01
Series:Journal of Applied Bioanalysis
Subjects:
17-aag
17-ag
bms-722782
tanespimycin
lc-ms/ms
protein precipitation
apci
in-source reduction
quinone.
Online Access:https://doi.org/10.17145/jab.20.015

Internet

https://doi.org/10.17145/jab.20.015

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