Synergistic Tumor Cytolysis by NK Cells in Combination With a Pan-HDAC Inhibitor, Panobinostat

Synergistic Tumor Cytolysis by NK Cells in Combination With a Pan-HDAC Inhibitor, Panobinostat

Histone deacetylases (HDAC) are frequently overexpressed in tumors, and their inhibition has shown promising anti-tumor effects. However, the synergistic effects of HDAC inhibition with immune cell therapy have not been fully explored. Natural killer (NK) cells are cytotoxic lymphocytes for anti-tum...

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Bibliographic Details
Main Authors: Lukman O. Afolabi, Jiacheng Bi, Xuguang Li, Adeleye O. Adeshakin, Funmilayo O. Adeshakin, Haisi Wu, Dehong Yan, Liang Chen, Xiaochun Wan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
HDAC
natural killer cells
cytotoxicity
chemotherapy
anti-PD-L1 therapy
immunomodulator
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.701671/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.701671/full

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