Angiocrine Sphingosine-1-Phosphate Activation of S1PR2-YAP Signaling Axis in Alveolar Type II Cells Is Essential for Lung Repair

Angiocrine Sphingosine-1-Phosphate Activation of S1PR2-YAP Signaling Axis in Alveolar Type II Cells Is Essential for Lung Repair

Summary: Lung alveolar epithelium is composed of alveolar type I (AT1) and type II (AT2) cells. AT1 cells mediate gas exchange, whereas AT2 cells act as progenitor cells to repair injured alveoli. Lung microvascular endothelial cells (LMVECs) play a crucial but still poorly understood role in regula...

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Bibliographic Details
Main Authors: Qian Chen, Jalees Rehman, Manwai Chan, Panfeng Fu, Steven M. Dudek, Viswanathan Natarajan, Asrar B. Malik, Yuru Liu
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Cell Reports
Subjects:
lung
alveoli
type II cells
niche
repair
endothelial
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720308093

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http://www.sciencedirect.com/science/article/pii/S2211124720308093

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