Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies

Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies

The highly conserved influenza virus hemagglutinin (HA) stalk represents a potential target for a broadly protective vaccine. Here, the authors show that immunization with nucleoside-modified mRNA encoding full-length HA formulated in lipid nanoparticles elicits HA stalk-specific antibodies and prot...

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Bibliographic Details
Main Authors: Norbert Pardi, Kaela Parkhouse, Ericka Kirkpatrick, Meagan McMahon, Seth J. Zost, Barbara L. Mui, Ying K. Tam, Katalin Karikó, Christopher J. Barbosa, Thomas D. Madden, Michael J. Hope, Florian Krammer, Scott E. Hensley, Drew Weissman
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05482-0

Internet

https://doi.org/10.1038/s41467-018-05482-0

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