A distributive peptide cyclase processes multiple microviridin core peptides within a single polypeptide substrate

Microviridins belong to the family of ribosomally synthesized and post-translationally modified peptides (RiPPs). Here, the authors discover a microviridin-synthesizing enzyme in a cyanobacterium that modifies multiple core peptides from a single substrate in a distributive and unstrictly directiona...

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Bibliographic Details
Main Authors: Yi Zhang, Kunhua Li, Guang Yang, Joshua L. McBride, Steven D. Bruner, Yousong Ding
Format: Article
Language:English
Published: Nature Publishing Group 2018-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04154-3