Secreted aspartic protease cleavage of Candida albicans Msb2 activates Cek1 MAPK signaling affecting biofilm formation and oropharyngeal candidiasis.

Secreted aspartic protease cleavage of Candida albicans Msb2 activates Cek1 MAPK signaling affecting biofilm formation and oropharyngeal candidiasis.

Perception of external stimuli and generation of an appropriate response are crucial for host colonization by pathogens. In pathogenic fungi, mitogen activated protein kinase (MAPK) pathways regulate dimorphism, biofilm/mat formation, and virulence. Signaling mucins, characterized by a heavily glyco...

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Bibliographic Details
Main Authors: Sumant Puri, Rohitashw Kumar, Sonia Chadha, Swetha Tati, Heather R Conti, Bernhard Hube, Paul J Cullen, Mira Edgerton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23139737/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23139737/?tool=EBI

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