Effects of crude flavonoids from tatary buckwheat on alloxan-induced oxidative stress in mice
The present study was undertaken to evaluate the effects of crude flavonoids from tatary buckwheat (FTB) on alloxan-induced oxidative stress in mice. After induction of diabetes, diabetic mice were randomly divided into four groups: one diabetic control group and three different doses of FTB (100,...
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Bangladesh Pharmacological Society
2012-07-01
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doaj-5347fc5bbb934416ae66247251a294972020-11-24T21:51:53ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882012-07-017210.3329/bjp.v7i2.10993Effects of crude flavonoids from tatary buckwheat on alloxan-induced oxidative stress in miceFayong Gong0Fenglin Li1Wanming Zhang2Jing Li3Zhong Zhang4School of Applied and Chemical Engineering, Xichang College, Sichuan Province 615000Key Laboratory of Metastable Materials Science & Technology, College of Materials Science and Engineering, Yanshan University, Hebei Province 066400School of Applied and Chemical Engineering, Xichang College, Sichuan Province, 615000School of Applied and Chemical Engineering, Xichang College, Sichuan Province 615000School of Applied and Chemical Engineering, Xichang College, Sichuan Province 615000 The present study was undertaken to evaluate the effects of crude flavonoids from tatary buckwheat (FTB) on alloxan-induced oxidative stress in mice. After induction of diabetes, diabetic mice were randomly divided into four groups: one diabetic control group and three different doses of FTB (100, 200 and 400 mg/kg) treated groups, with non-diabetic mice used as the normal control group. The mice were intragastrically administered once daily for 28 days. Fasting blood glucose (FBG), serum insulin, superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and malondialdehyde (MDA) were measured. The results showed that FTB could significantly reduce FBG levels and MDA contents, and increase serum insulin levels, SOD, GPx and CAT activities. These data suggested that FTB possess hypoglycemic effects and could reduce alloxan-induced oxidative stress in mice. Therefore, FTB might be of use as an antidiabetic drug. https://www.banglajol.info/index.php/BJP/article/view/10993AlloxanFlavonoidMiceOxidative stressTatary buckwheat |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fayong Gong Fenglin Li Wanming Zhang Jing Li Zhong Zhang |
spellingShingle |
Fayong Gong Fenglin Li Wanming Zhang Jing Li Zhong Zhang Effects of crude flavonoids from tatary buckwheat on alloxan-induced oxidative stress in mice Bangladesh Journal of Pharmacology Alloxan Flavonoid Mice Oxidative stress Tatary buckwheat |
author_facet |
Fayong Gong Fenglin Li Wanming Zhang Jing Li Zhong Zhang |
author_sort |
Fayong Gong |
title |
Effects of crude flavonoids from tatary buckwheat on alloxan-induced oxidative stress in mice |
title_short |
Effects of crude flavonoids from tatary buckwheat on alloxan-induced oxidative stress in mice |
title_full |
Effects of crude flavonoids from tatary buckwheat on alloxan-induced oxidative stress in mice |
title_fullStr |
Effects of crude flavonoids from tatary buckwheat on alloxan-induced oxidative stress in mice |
title_full_unstemmed |
Effects of crude flavonoids from tatary buckwheat on alloxan-induced oxidative stress in mice |
title_sort |
effects of crude flavonoids from tatary buckwheat on alloxan-induced oxidative stress in mice |
publisher |
Bangladesh Pharmacological Society |
series |
Bangladesh Journal of Pharmacology |
issn |
1991-0088 |
publishDate |
2012-07-01 |
description |
The present study was undertaken to evaluate the effects of crude flavonoids from tatary buckwheat (FTB) on alloxan-induced oxidative stress in mice. After induction of diabetes, diabetic mice were randomly divided into four groups: one diabetic control group and three different doses of FTB (100, 200 and 400 mg/kg) treated groups, with non-diabetic mice used as the normal control group. The mice were intragastrically administered once daily for 28 days. Fasting blood glucose (FBG), serum insulin, superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and malondialdehyde (MDA) were measured. The results showed that FTB could significantly reduce FBG levels and MDA contents, and increase serum insulin levels, SOD, GPx and CAT activities. These data suggested that FTB possess hypoglycemic effects and could reduce alloxan-induced oxidative stress in mice. Therefore, FTB might be of use as an antidiabetic drug.
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topic |
Alloxan Flavonoid Mice Oxidative stress Tatary buckwheat |
url |
https://www.banglajol.info/index.php/BJP/article/view/10993 |
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