A Batf3/Nlrp3/IL-18 Axis Promotes Natural Killer Cell IL-10 Production during Listeria monocytogenes Infection

A Batf3/Nlrp3/IL-18 Axis Promotes Natural Killer Cell IL-10 Production during Listeria monocytogenes Infection

The bacterial pathogen Listeria monocytogenes (Lm) capitalizes on natural killer (NK) cell production of regulatory interleukin (IL)-10 to establish severe systemic infections. Here, we identify regulators of this IL-10 secretion. We show that IL-18 signals to NK cells license their ability to produ...

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Bibliographic Details
Main Authors: Sarah E. Clark, Rebecca L. Schmidt, Daniel S. McDermott, Laurel L. Lenz
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Cell Reports
Subjects:
Natural killer cell
infection
Listeria monocytogenes
dendritic cell
interleukin-10
interleukin-18
Nlrp3
Batf3
immune regulation
innate immunity
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718307046

Internet

http://www.sciencedirect.com/science/article/pii/S2211124718307046

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