CDK13 upregulation-induced formation of the positive feedback loop among circCDK13, miR-212-5p/miR-449a and E2F5 contributes to prostate carcinogenesis

CDK13 upregulation-induced formation of the positive feedback loop among circCDK13, miR-212-5p/miR-449a and E2F5 contributes to prostate carcinogenesis

Abstract Background Both E2F transcription factor and cyclin-dependent kinases (CDKs), which increase or decrease E2F activity by phosphorylating E2F or its partner, are involved in the control of cell proliferation, and some circRNAs and miRNAs regulate the expression of E2F and CDKs. However, litt...

Full description

Bibliographic Details
Main Authors: Jin-Chun Qi, Zhan Yang, Tao Lin, Long Ma, Ya-Xuan Wang, Yong Zhang, Chun-Cheng Gao, Kai-Long Liu, Wei Li, An-Ning Zhao, Bei Shi, Hong Zhang, Dan-Dan Wang, Xiao-Lu Wang, Jin-Kun Wen, Chang-Bao Qu
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Prostate cancer
CDK13
circRNAs biogenesis
E2F5
Drug resistance
Online Access:https://doi.org/10.1186/s13046-020-01814-5

Internet

https://doi.org/10.1186/s13046-020-01814-5

Similar Items