Reprogramming of Dermal Fibroblasts into Osteo-Chondrogenic Cells with Elevated Osteogenic Potency by Defined Transcription Factors

Reprogramming of Dermal Fibroblasts into Osteo-Chondrogenic Cells with Elevated Osteogenic Potency by Defined Transcription Factors

Recent studies using defined transcription factors to convert skin fibroblasts into chondrocytes have raised the question of whether osteo-chondroprogenitors expressing SOX9 and RUNX2 could also be generated during the course of the reprogramming process. Here, we demonstrated that doxycycline-induc...

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Bibliographic Details
Main Authors: Yinxiang Wang, Ming-Hoi Wu, May Pui Lai Cheung, Mai Har Sham, Haruhiko Akiyama, Danny Chan, Kathryn S.E. Cheah, Martin Cheung
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Stem Cell Reports
Subjects:
chondrocytes
osteoblasts
osteo-chondroprogenitors
reprogramming
SOX9
RUNX2
c-MYC
KLF4
limb bud
lentiviruses
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117301728

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http://www.sciencedirect.com/science/article/pii/S2213671117301728

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