Horizontal acquisition of a hypoxia-responsive molybdenum cofactor biosynthesis pathway contributed to Mycobacterium tuberculosis pathoadaptation.

Horizontal acquisition of a hypoxia-responsive molybdenum cofactor biosynthesis pathway contributed to Mycobacterium tuberculosis pathoadaptation.

The unique ability of the tuberculosis (TB) bacillus, Mycobacterium tuberculosis, to persist for long periods of time in lung hypoxic lesions chiefly contributes to the global burden of latent TB. We and others previously reported that the M. tuberculosis ancestor underwent massive episodes of horiz...

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Bibliographic Details
Main Authors: Florence Levillain, Yannick Poquet, Ludovic Mallet, Serge Mazères, Michael Marceau, Roland Brosch, Franz-Christoph Bange, Philip Supply, Axel Magalon, Olivier Neyrolles
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-11-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1006752

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https://doi.org/10.1371/journal.ppat.1006752

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