Bortezomib-induced painful peripheral neuropathy: an electrophysiological, behavioral, morphological and mechanistic study in the mouse.

Bortezomib is the first proteasome inhibitor with significant antineoplastic activity for the treatment of relapsed/refractory multiple myeloma as well as other hematological and solid neoplasms. Peripheral neurological complications manifesting with paresthesias, burning sensations, dysesthesias, n...

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Main Authors: Valentina A Carozzi, Cynthia L Renn, Michela Bardini, Grazia Fazio, Alessia Chiorazzi, Cristina Meregalli, Norberto Oggioni, Kathleen Shanks, Marina Quartu, Maria Pina Serra, Barbara Sala, Guido Cavaletti, Susan G Dorsey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3772181?pdf=render