The biological activity of 3α-hydroxysteroid oxido-reductase in the spinal cord regulates thermal and mechanical pain thresholds after sciatic nerve injury

The biological activity of 3α-hydroxysteroid oxido-reductase in the spinal cord regulates thermal and mechanical pain thresholds after sciatic nerve injury

Identification of cellular targets pertinent for the development of effective therapies against pathological pain constitutes a difficult challenge. We combined several approaches to show that 3α-hydroxysteroid oxido-reductase (3α-HSOR), abundantly expressed in the spinal cord (SC), is a key target,...

Full description

Bibliographic Details
Main Authors: Laurence Meyer, Christine Venard, Véronique Schaeffer, Christine Patte-Mensah, Ayikoe G. Mensah-Nyagan
Format: Article
Language:English
Published: Elsevier 2008-04-01
Series:Neurobiology of Disease
Subjects:
Allodynia
Neuropathy
Neurobiology of pain
Neurosteroid
Sciatic nerve constriction
Spinal cord
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107002689

Internet

http://www.sciencedirect.com/science/article/pii/S0969996107002689

Similar Items