Upregulation of miR-370 and miR-543 is associated with reduced expression of heat shock protein 40 in spinocerebellar ataxia type 3.

Upregulation of miR-370 and miR-543 is associated with reduced expression of heat shock protein 40 in spinocerebellar ataxia type 3.

Molecular chaperones are important regulators of protein folding and proteasomal removal of misfolded proteins. In spinocerebellar ataxia type 3 (SCA3), the co-chaperone DnaJ homology subfamily B member 1 (DNAJB1 or heat shock protein 40) is recruited to protein aggregates formed by the disease-caus...

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Bibliographic Details
Main Authors: Bernd O Evert, Rohit Nalavade, Johannes Jungverdorben, Frank Matthes, Stephanie Weber, Ashish Rajput, Stefan Bonn, Oliver Brüstle, Michael Peitz, Sybille Krauß
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6080806?pdf=render

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http://europepmc.org/articles/PMC6080806?pdf=render

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