Co-stimulation modulation improves Rheumatoid Arthritis despite reducing the proportion of CD4+CD25high T regulatory cells
Objective/Aims: Cytotoxic T Lymphocyte Antigen-4 (CTLA-4) is constitutively expressed on the surface of regulatory T cells (Treg), although its function in this context remains unclear. Abatacept, a soluble CTLA-4·Ig construct is a co-stimulation modulator that is used for the treatment of rheumatoi...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
PCO Convin S.A.
2016-01-01
|
| Series: | Mediterranean Journal of Rheumatology |
| Subjects: | |
| Online Access: | https://www.mjrheum.org/assets/files/792/file32_567.pdf |