Heterochromatin and RNAi regulate centromeres by protecting CENP-A from ubiquitin-mediated degradation.
Centromere is a specialized chromatin domain that plays a vital role in chromosome segregation. In most eukaryotes, centromere is surrounded by the epigenetically distinct heterochromatin domain. Heterochromatin has been shown to contribute to centromere function, but the precise role of heterochrom...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-08-01
|
| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC6101405?pdf=render |