Nevirapine Biotransformation Insights: An Integrated In Vitro Approach Unveils the Biocompetence and <i>Glutathiolomic</i> Profile of a Human Hepatocyte-Like Cell 3D Model

Nevirapine Biotransformation Insights: An Integrated In Vitro Approach Unveils the Biocompetence and <i>Glutathiolomic</i> Profile of a Human Hepatocyte-Like Cell 3D Model

The need for competent in vitro liver models for toxicological assessment persists. The differentiation of stem cells into hepatocyte-like cells (HLC) has been adopted due to its human origin and availability. Our aim was to study the usefulness of an in vitro 3D model of mesenchymal stem cell-deriv...

Full description

Bibliographic Details
Main Authors: Madalena Cipriano, Pedro F Pinheiro, Catarina O Sequeira, Joana S Rodrigues, Nuno G Oliveira, Alexandra M M Antunes, Matilde Castro, M Matilde Marques, Sofia A Pereira, Joana P Miranda
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
hepatocytes
nevirapine
stem cells
3D culture
glutathione
metabolism
Online Access:https://www.mdpi.com/1422-0067/21/11/3998

Internet

https://www.mdpi.com/1422-0067/21/11/3998

Similar Items