Decreased dengue replication and an increased anti-viral humoral response with the use of combined Toll-like receptor 3 and 7/8 agonists in macaques.

Decreased dengue replication and an increased anti-viral humoral response with the use of combined Toll-like receptor 3 and 7/8 agonists in macaques.

Pathogenic versus protective outcomes to Dengue virus (DENV) infection are associated with innate immune function. This study aimed to determine the role of increased TLR3- and TLR7/8-mediated innate signaling after Dengue infection of rhesus macaques in vivo to evaluate its impact on disease and an...

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Bibliographic Details
Main Authors: Carlos A Sariol, Melween I Martínez, Francheska Rivera, Idia Vanessa Rodríguez, Petraleigh Pantoja, Kristina Abel, Teresa Arana, Luis Giavedoni, Vida Hodara, Laura J White, Yesseinia I Angleró, Luis J Montaner, Edmundo N Kraiselburd
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3084804?pdf=render

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http://europepmc.org/articles/PMC3084804?pdf=render

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