Mycobacteria-Specific T Cells May Be Expanded From Healthy Donors and Are Near Absent in Primary Immunodeficiency Disorders

Mycobacteria-Specific T Cells May Be Expanded From Healthy Donors and Are Near Absent in Primary Immunodeficiency Disorders

Mycobacterial Infections can be severe in patients with T-cell deficiency or phagocyte disorders, and treatment is frequently complicated by antimicrobial resistance. Restoration of T-cell immunity via stem cell transplantation facilitates control of mycobacterial infections, but presence of active...

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Bibliographic Details
Main Authors: Shabnum Patel, Haili Lang, Gelina Sani, Alexandra F. Freeman, Jennifer Leiding, Patrick J. Hanley, Conrad Russell Cruz, Melanie Grant, Yunfei Wang, Benjamin Oshrine, Cindy Palmer, Steven M. Holland, Catherine M. Bollard, Michael D. Keller
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
immunotherapy
T cells
mycobacteria
primary immunodeficiency
mendelian suspectibility to mycobacteria
hematopoietic stem cell transplantation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00621/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00621/full

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