Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB

Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB

Membrane transporters of the RND superfamily confer multidrug resistance to pathogenic bacteria, and are essential for cholesterol metabolism and embryonic development in humans. We use high-resolution X-ray crystallography and computational methods to delineate the mechanism of the homotrimeric RND...

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Bibliographic Details
Main Authors: Thomas Eicher, Markus A Seeger, Claudio Anselmi, Wenchang Zhou, Lorenz Brandstätter, François Verrey, Kay Diederichs, José D Faraldo-Gómez, Klaas M Pos
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-09-01
Series:eLife
Subjects:
antibiotic resistance
efflux pump
drug transport
H+ transport
mechanistic coupling
drug resistance
Online Access:https://elifesciences.org/articles/03145

Internet

https://elifesciences.org/articles/03145

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