CYP7A1 promoter polymorphism −203A>C affects bile salt synthesis rate in patients after ileal resection

Cholesterol 7α-hydroxylase (CYP7A1) plays a crucial role in cholesterol metabolism and has been implicated in genetic susceptibility to atherosclerosis. Thus, an understanding of its transcriptional regulation is of considerable importance. We evaluated the effect of a common −203A>C polymorphism...

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Bibliographic Details
Main Authors: Martin Leníček, Viktor Komárek, Miluše Zimolová, Jan Kovář, Milan Jirsa, Milan Lukáš, Libor Vítek
Format: Article
Language:English
Published: Elsevier 2008-12-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520345971