Chronic central administration of Ghrelin increases bone mass through a mechanism independent of appetite regulation.

Chronic central administration of Ghrelin increases bone mass through a mechanism independent of appetite regulation.

Leptin plays a critical role in the central regulation of bone mass. Ghrelin counteracts leptin. In this study, we investigated the effect of chronic intracerebroventricular administration of ghrelin on bone mass in Sprague-Dawley rats (1.5 μg/day for 21 days). Rats were divided into control, ghreli...

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Bibliographic Details
Main Authors: Hyung Jin Choi, Kyoung Ho Ki, Jae-Yeon Yang, Bo Young Jang, Jung Ah Song, Wook-Young Baek, Jung Hee Kim, Jee Hyun An, Sang Wan Kim, Seong Yeon Kim, Jung-Eun Kim, Chan Soo Shin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3699588?pdf=render

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http://europepmc.org/articles/PMC3699588?pdf=render

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