Safety and Immunogenicity of a Recombinant Tetanus Vaccine in Healthy Adults in China: A Randomized, Double‐Blind, Dose Escalation, Placebo‐ and Positive‐Controlled, Phase 1/2 Trial

Safety and Immunogenicity of a Recombinant Tetanus Vaccine in Healthy Adults in China: A Randomized, Double‐Blind, Dose Escalation, Placebo‐ and Positive‐Controlled, Phase 1/2 Trial

Abstract Tetanus is a fatal but vaccine‐preventable disease. The currently available tetanus vaccines are tetanus toxoid (TT)‐based. Although these vaccines are generally effective, challenges in vaccine development and access remain. A randomized, double‐blind, dose escalation, placebo‐ and positiv...

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Bibliographic Details
Main Authors: Xiaowei Xu, Rui Yu, Lanlan Xiao, Jie Wang, Meihong Yu, Junjie Xu, Yajun Tan, Xiao Ma, Xiaoxin Wu, Jiangshan Lian, Kaizhou Huang, Xiaoxi Ouyang, Sheng Bi, Shipo Wu, Xiaoyan Wang, Jiandi Jin, Ling Yu, Huafen Zhang, Qi Wei, Jinfa Shi, Wei Chen, Lanjuan Li
Format: Article
Language:English
Published: Wiley 2021-08-01
Series:Advanced Science
Subjects:
recombinant tetanus vaccine
tetanus
tetanus toxoid vaccine
Online Access:https://doi.org/10.1002/advs.202002751

Internet

https://doi.org/10.1002/advs.202002751

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