Myostatin inhibition slows muscle atrophy in rodent models of amyotrophic lateral sclerosis

Myostatin inhibition slows muscle atrophy in rodent models of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease leading to motor neuron cell death, but recent studies suggest that non-neuronal cells may contribute to the pathological mechanisms involved. Myostatin is a negative regulator of muscle growth whose function can be inhibi...

Full description

Bibliographic Details
Main Authors: Erika L.F. Holzbaur, David S. Howland, Nicholas Weber, Karen Wallace, Yijin She, Seung Kwak, Lioudmilla A. Tchistiakova, Erin Murphy, Joseph Hinson, Riyez Karim, Xiang Yang Tan, Pamela Kelley, Kevin C. McGill, Gareth Williams, Carl Hobbs, Patrick Doherty, Margaret M. Zaleska, Menelas N. Pangalos, Frank S. Walsh
Format: Article
Language:English
Published: Elsevier 2006-09-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis
SOD1
Myostatin
GDF-8
Motor neuron disease
Motor neuron degeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106001379

Internet

http://www.sciencedirect.com/science/article/pii/S0969996106001379

Similar Items