Dual Inhibition of γ-Tubulin and Plk1 Induces Mitotic Cell Death

Dual Inhibition of γ-Tubulin and Plk1 Induces Mitotic Cell Death

α/β-Tubulin inhibitors that alter microtubule (MT) dynamics are commonly used in cancer therapy, however, these inhibitors also cause severe side effects such as peripheral neuropathy. γ-Tubulin is a possible target as antitumor drugs with low side effects, but the antitumor effect of γ-tubulin inhi...

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Bibliographic Details
Main Authors: Haruna Ebisu, Kana Shintani, Takumi Chinen, Yoko Nagumo, Shuya Shioda, Taisei Hatanaka, Akira Sakakura, Ichiro Hayakawa, Hideo Kigoshi, Takeo Usui
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
gatastatin
γ-tubulin
plk1
mitotic apoptosis
drug combination
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.620185/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.620185/full

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