Metals and cholesterol: two sides of the same coin in Alzheimer’s disease pathology

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease. It begins years prior to the onset of clinical symptoms, such as memory loss and cognitive decline. Pathological hallmarks of AD include the accumulation of β-amyloid in plaques and hyperphosphorylated tau in neurofibrillary...

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Bibliographic Details
Main Authors: Bruce Xue Wen Wong, Ya Hui eHung, Ashley Ian Bush, James Alex Duce
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00091/full