Metals and cholesterol: two sides of the same coin in Alzheimer’s disease pathology
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease. It begins years prior to the onset of clinical symptoms, such as memory loss and cognitive decline. Pathological hallmarks of AD include the accumulation of β-amyloid in plaques and hyperphosphorylated tau in neurofibrillary...
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2014-05-01
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doaj-5389425eee4040d39223d3ee7c44b6022020-11-24T20:40:28ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652014-05-01610.3389/fnagi.2014.0009188361Metals and cholesterol: two sides of the same coin in Alzheimer’s disease pathologyBruce Xue Wen Wong0Ya Hui eHung1Ashley Ian Bush2James Alex Duce3James Alex Duce4The University of MelbourneThe University of MelbourneThe University of MelbourneThe University of MelbourneUniversity of LeedsAlzheimer’s disease (AD) is a multifactorial neurodegenerative disease. It begins years prior to the onset of clinical symptoms, such as memory loss and cognitive decline. Pathological hallmarks of AD include the accumulation of β-amyloid in plaques and hyperphosphorylated tau in neurofibrillary tangles. Copper, iron and zinc are abnormally accumulated and distributed in the aging brain. These metal ions can adversely contribute to the progression of AD. Dysregulation of cholesterol metabolism has also been implicated in the development of AD pathology. To date, large bodies of research have been carried out independently to elucidate the role of metals or cholesterol on AD pathology. Interestingly, metals and cholesterol affect parallel molecular and biochemical pathways involved in AD pathology. The possible links between metal dyshomeostasis and altered brain cholesterol metabolism in AD are reviewed.http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00091/fullCholesterolCopperIronMetalsZincAlzheimer’s disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bruce Xue Wen Wong Ya Hui eHung Ashley Ian Bush James Alex Duce James Alex Duce |
spellingShingle |
Bruce Xue Wen Wong Ya Hui eHung Ashley Ian Bush James Alex Duce James Alex Duce Metals and cholesterol: two sides of the same coin in Alzheimer’s disease pathology Frontiers in Aging Neuroscience Cholesterol Copper Iron Metals Zinc Alzheimer’s disease |
author_facet |
Bruce Xue Wen Wong Ya Hui eHung Ashley Ian Bush James Alex Duce James Alex Duce |
author_sort |
Bruce Xue Wen Wong |
title |
Metals and cholesterol: two sides of the same coin in Alzheimer’s disease pathology |
title_short |
Metals and cholesterol: two sides of the same coin in Alzheimer’s disease pathology |
title_full |
Metals and cholesterol: two sides of the same coin in Alzheimer’s disease pathology |
title_fullStr |
Metals and cholesterol: two sides of the same coin in Alzheimer’s disease pathology |
title_full_unstemmed |
Metals and cholesterol: two sides of the same coin in Alzheimer’s disease pathology |
title_sort |
metals and cholesterol: two sides of the same coin in alzheimer’s disease pathology |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Aging Neuroscience |
issn |
1663-4365 |
publishDate |
2014-05-01 |
description |
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease. It begins years prior to the onset of clinical symptoms, such as memory loss and cognitive decline. Pathological hallmarks of AD include the accumulation of β-amyloid in plaques and hyperphosphorylated tau in neurofibrillary tangles. Copper, iron and zinc are abnormally accumulated and distributed in the aging brain. These metal ions can adversely contribute to the progression of AD. Dysregulation of cholesterol metabolism has also been implicated in the development of AD pathology. To date, large bodies of research have been carried out independently to elucidate the role of metals or cholesterol on AD pathology. Interestingly, metals and cholesterol affect parallel molecular and biochemical pathways involved in AD pathology. The possible links between metal dyshomeostasis and altered brain cholesterol metabolism in AD are reviewed. |
topic |
Cholesterol Copper Iron Metals Zinc Alzheimer’s disease |
url |
http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00091/full |
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