Adeno-associated viral vector-mediated gene transfer of brain-derived neurotrophic factor reverses atrophy of rubrospinal neurons following both acute and chronic spinal cord injury

Adeno-associated viral vector-mediated gene transfer of brain-derived neurotrophic factor reverses atrophy of rubrospinal neurons following both acute and chronic spinal cord injury

Rubrospinal neurons (RSNs) undergo marked atrophy after cervical axotomy. This progressive atrophy may impair the regenerative capacity of RSNs in response to repair strategies that are targeted to promote rubrospinal tract regeneration. Here, we investigated whether we could achieve long-term rescu...

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Bibliographic Details
Main Authors: Marc J Ruitenberg, Bas Blits, Paul A Dijkhuizen, Erik T te Beek, Arne Bakker, Joop J van Heerikhuize, Chris W Pool, Wim T.J Hermens, Gerard J Boer, Joost Verhaagen
Format: Article
Language:English
Published: Elsevier 2004-03-01
Series:Neurobiology of Disease
Subjects:
Adeno-associated viral vector
Atrophy
Brain-derived neurotrophic factor
Gene therapy
Regeneration
Rubrospinal tract
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996103002572

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http://www.sciencedirect.com/science/article/pii/S0969996103002572

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