Combined in Vitro and in Silico Studies for the Anticholinesterase Activity and Pharmacokinetics of Coumarinyl Thiazoles and Oxadiazoles

Combined in Vitro and in Silico Studies for the Anticholinesterase Activity and Pharmacokinetics of Coumarinyl Thiazoles and Oxadiazoles

In a continuation of our previous work for the exploration of novel enzyme inhibitors, two new coumarin-thiazole 6(a–o) and coumarin-oxadiazole 11(a–h) hybrids have been designed and synthesized. All the compounds were characterized by 1H- and 13C-NMR spectroscopy and elemental analysis. New hybrid...

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Bibliographic Details
Main Authors: Aliya Ibrar, Ajmal Khan, Majid Ali, Rizwana Sarwar, Saifullah Mehsud, Umar Farooq, Syed M. A. Halimi, Imtiaz Khan, Ahmed Al-Harrasi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Chemistry
Subjects:
coumarin thiazoles
coumarin oxadiazoles
cholinesterase inhibition
molecular docking
MOE score
Online Access:http://journal.frontiersin.org/article/10.3389/fchem.2018.00061/full

Internet

http://journal.frontiersin.org/article/10.3389/fchem.2018.00061/full

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