Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis

Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis

Cell-based studies showed that several Mdm2-binding ribosomal proteins, upon overexpression, stabilize and activate p53. In contrast, here we show in a mouse knockout study that Mdm2-binding ribosomal protein S27-like (Rps27l), upon disruption, activates p53. Germline inactivation of Rps27l triggers...

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Bibliographic Details
Main Authors: Xiufang Xiong, Yongchao Zhao, Fei Tang, Dongping Wei, Daffyd Thomas, Xiang Wang, Yang Liu, Pan Zheng, Yi Sun
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-08-01
Series:eLife
Subjects:
p53
Mdm2-Mdm4
ribosomal protein
mouse knockout
aneuploidy
tumorigenesis
Online Access:https://elifesciences.org/articles/02236

Internet

https://elifesciences.org/articles/02236

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