Pleiotropic and diverse expression of ZFHX1B gene transcripts during mouse and human development supports the various clinical manifestations of the “Mowat–Wilson” syndrome

Pleiotropic and diverse expression of ZFHX1B gene transcripts during mouse and human development supports the various clinical manifestations of the “Mowat–Wilson” syndrome

ZFHX1B encodes Smad-interacting protein 1, a transcriptional corepressor involved in the transforming growth factors β (TGFβ) signaling pathway. ZFHX1B mutations cause a complex developmental phenotype characterized by severe mental retardation (MR) and multiple congenital defects. We compared the d...

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Bibliographic Details
Main Authors: Guillaume Bassez, Olivier J.A Camand, Valère Cacheux, Alexandra Kobetz, Florence Dastot-Le Moal, Dominique Marchant, Martin Catala, Marc Abitbol, Michel Goossens
Format: Article
Language:English
Published: Elsevier 2004-03-01
Series:Neurobiology of Disease
Subjects:
Cardiovascular system
Human and mouse development
mRNA species
Neurogenesis
Smad-interacting protein-1 (SIP1)
TGF-beta signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996103002080

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http://www.sciencedirect.com/science/article/pii/S0969996103002080

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