Preventive effects of crocin on neuronal damages induced by D-galactose through AGEs and oxidative stress in human neuroblastoma cells (SH-SY5Y)

Preventive effects of crocin on neuronal damages induced by D-galactose through AGEs and oxidative stress in human neuroblastoma cells (SH-SY5Y)

Objective:D-galactose (D-gal) is well-known agent to induce aging process. In the present study, we selected crocin, the main constituent of Crocus sativus L. (saffron), against D-gal- induced cytotoxicity in human neuroblastoma SH-SY5Y cells.Methods:Pretreated cells with crocin (25-500 μM, 24 h) we...

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Bibliographic Details
Main Authors: Somaye Heidari, Soghra Mehri, Vahidesadat Shariaty, Hossein Hosseinzadeh
Format: Article
Language:English
Published: Korean Pharmacopuncture Institute 2018-03-01
Series:Journal of Pharmacopuncture
Subjects:
d-galactose
crocin
saffron
aging
reactive oxygen species
advanced glycation end products
Online Access:http://www.journal-pharm.com/sub/view/236

Internet

http://www.journal-pharm.com/sub/view/236

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