Unravelling druggable signalling networks that control F508del-CFTR proteostasis

Unravelling druggable signalling networks that control F508del-CFTR proteostasis

Cystic fibrosis (CF) is caused by mutations in CF transmembrane conductance regulator (CFTR). The most frequent mutation (F508del-CFTR) results in altered proteostasis, that is, in the misfolding and intracellular degradation of the protein. The F508del-CFTR proteostasis machinery and its homeostati...

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Bibliographic Details
Main Authors: Ramanath Narayana Hegde, Seetharaman Parashuraman, Francesco Iorio, Fabiana Ciciriello, Fabrizio Capuani, Annamaria Carissimo, Diego Carrella, Vincenzo Belcastro, Advait Subramanian, Laura Bounti, Maria Persico, Graeme Carlile, Luis Galietta, David Y Thomas, Diego Di Bernardo, Alberto Luini
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-12-01
Series:eLife
Subjects:
cystic fibrosis
proteostasis regulators
signalling networks
mechanism of action of drugs
CFTR
Online Access:https://elifesciences.org/articles/10365

Internet

https://elifesciences.org/articles/10365

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