(Pro)renin receptor antagonist PRO20 attenuates nephrectomy‐induced nephropathy in rats via inhibition of intrarenal RAS and Wnt/β‐catenin signaling

(Pro)renin receptor antagonist PRO20 attenuates nephrectomy‐induced nephropathy in rats via inhibition of intrarenal RAS and Wnt/β‐catenin signaling

Abstract Introduction (Pro)renin receptor has emerged as a new member of the renin‐angiotensin system implicated in the pathogenesis of chronic kidney disease (CKD). Herein we report characterization of the therapeutic potential of (pro)renin receptor (PRR) antagonist PRO20 in 5/6 nephrectomy (5/6Nx...

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Bibliographic Details
Main Authors: Yan Wang, Yurong Wang, Kai Xue, Huaijie Wang, Jingjing Zhou, Feng Gao, Chengde Li, Tianxin Yang, Hui Fang
Format: Article
Language:English
Published: Wiley 2021-06-01
Series:Physiological Reports
Subjects:
5/6 nephrectomy
(Pro)renin receptor
renin‐angiotensin system
Online Access:https://doi.org/10.14814/phy2.14881

Internet

https://doi.org/10.14814/phy2.14881

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