Generation of interspecies mouse-rat chimeric embryos by embryonic stem (ES) cell microinjection

Summary: Interspecies chimerism is a useful tool to study interactions between cells of different genetic makeup in order to elucidate the mechanisms underlying non-cell-autonomous processes, including evolutionary events. However, generating interspecies chimeras with high efficiency and chimerism...

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Bibliographic Details
Main Authors: Barbara K. Stepien, Samir Vaid, Ronald Naumann, Anja Holtz, Wieland B. Huttner
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:STAR Protocols
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S266616672100201X