Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion

Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion

This study describes the effect of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as tumor necrosis factor alpha (TNF-á) production inhibitors. The newly synthesized compounds were tested for their in vitro ability to inhibit the lipolysaccharide (LPS) induced TNF-á secretion in the human p...

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Bibliographic Details
Main Authors: GLORIA D GALARCE, ROCÍO E FONCEA, ANA M EDWARDS, HERNÁN PESSOA-MAHANA, CARLOS D PESSOA-MAHANA, ROBERTO A EBENSPERGER
Format: Article
Language:English
Published: BMC 2008-01-01
Series:Biological Research
Subjects:
anti-inflammatory agents
benzimidazoquinazoline derivatives
TNF-á inhibitors
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000100006

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http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000100006

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