Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion
This study describes the effect of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as tumor necrosis factor alpha (TNF-á) production inhibitors. The newly synthesized compounds were tested for their in vitro ability to inhibit the lipolysaccharide (LPS) induced TNF-á secretion in the human p...
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doaj-53a531384e474277826538382d5b8c762020-11-24T22:06:42ZengBMCBiological Research0716-97600717-62872008-01-014114350Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretionGLORIA D GALARCEROCÍO E FONCEAANA M EDWARDSHERNÁN PESSOA-MAHANACARLOS D PESSOA-MAHANAROBERTO A EBENSPERGERThis study describes the effect of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as tumor necrosis factor alpha (TNF-á) production inhibitors. The newly synthesized compounds were tested for their in vitro ability to inhibit the lipolysaccharide (LPS) induced TNF-á secretion in the human promyelocytic cell line HL-60. The compound 6-Phenyl-benzimidazo [1,2-c] quinazoline, coded as Gl, resulted as the most potent inhibitor and with no significant cytotoxic activity. Thus, 6-Arylbenzimidazo [1,2-c] quinazoline derivatives may have a potential as anti-inflammatory agentshttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000100006anti-inflammatory agentsbenzimidazoquinazoline derivativesTNF-á inhibitors |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
GLORIA D GALARCE ROCÍO E FONCEA ANA M EDWARDS HERNÁN PESSOA-MAHANA CARLOS D PESSOA-MAHANA ROBERTO A EBENSPERGER |
spellingShingle |
GLORIA D GALARCE ROCÍO E FONCEA ANA M EDWARDS HERNÁN PESSOA-MAHANA CARLOS D PESSOA-MAHANA ROBERTO A EBENSPERGER Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion Biological Research anti-inflammatory agents benzimidazoquinazoline derivatives TNF-á inhibitors |
author_facet |
GLORIA D GALARCE ROCÍO E FONCEA ANA M EDWARDS HERNÁN PESSOA-MAHANA CARLOS D PESSOA-MAHANA ROBERTO A EBENSPERGER |
author_sort |
GLORIA D GALARCE |
title |
Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion |
title_short |
Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion |
title_full |
Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion |
title_fullStr |
Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion |
title_full_unstemmed |
Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion |
title_sort |
biological evaluation of novel 6-arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of lps-induced tnf- alpha secretion |
publisher |
BMC |
series |
Biological Research |
issn |
0716-9760 0717-6287 |
publishDate |
2008-01-01 |
description |
This study describes the effect of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as tumor necrosis factor alpha (TNF-á) production inhibitors. The newly synthesized compounds were tested for their in vitro ability to inhibit the lipolysaccharide (LPS) induced TNF-á secretion in the human promyelocytic cell line HL-60. The compound 6-Phenyl-benzimidazo [1,2-c] quinazoline, coded as Gl, resulted as the most potent inhibitor and with no significant cytotoxic activity. Thus, 6-Arylbenzimidazo [1,2-c] quinazoline derivatives may have a potential as anti-inflammatory agents |
topic |
anti-inflammatory agents benzimidazoquinazoline derivatives TNF-á inhibitors |
url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000100006 |
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