Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion

Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion

This study describes the effect of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as tumor necrosis factor alpha (TNF-á) production inhibitors. The newly synthesized compounds were tested for their in vitro ability to inhibit the lipolysaccharide (LPS) induced TNF-á secretion in the human p...

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Main Authors: GLORIA D GALARCE, ROCÍO E FONCEA, ANA M EDWARDS, HERNÁN PESSOA-MAHANA, CARLOS D PESSOA-MAHANA, ROBERTO A EBENSPERGER
Format: Article
Language:English
Published: BMC 2008-01-01
Series:Biological Research
Subjects:
anti-inflammatory agents
benzimidazoquinazoline derivatives
TNF-á inhibitors
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000100006
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spelling doaj-53a531384e474277826538382d5b8c762020-11-24T22:06:42ZengBMCBiological Research0716-97600717-62872008-01-014114350Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretionGLORIA D GALARCEROCÍO E FONCEAANA M EDWARDSHERNÁN PESSOA-MAHANACARLOS D PESSOA-MAHANAROBERTO A EBENSPERGERThis study describes the effect of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as tumor necrosis factor alpha (TNF-á) production inhibitors. The newly synthesized compounds were tested for their in vitro ability to inhibit the lipolysaccharide (LPS) induced TNF-á secretion in the human promyelocytic cell line HL-60. The compound 6-Phenyl-benzimidazo [1,2-c] quinazoline, coded as Gl, resulted as the most potent inhibitor and with no significant cytotoxic activity. Thus, 6-Arylbenzimidazo [1,2-c] quinazoline derivatives may have a potential as anti-inflammatory agentshttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000100006anti-inflammatory agentsbenzimidazoquinazoline derivativesTNF-á inhibitors
collection DOAJ
language English
format Article
sources DOAJ
author GLORIA D GALARCE
ROCÍO E FONCEA
ANA M EDWARDS
HERNÁN PESSOA-MAHANA
CARLOS D PESSOA-MAHANA
ROBERTO A EBENSPERGER
spellingShingle GLORIA D GALARCE
ROCÍO E FONCEA
ANA M EDWARDS
HERNÁN PESSOA-MAHANA
CARLOS D PESSOA-MAHANA
ROBERTO A EBENSPERGER
Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion
Biological Research
anti-inflammatory agents
benzimidazoquinazoline derivatives
TNF-á inhibitors
author_facet GLORIA D GALARCE
ROCÍO E FONCEA
ANA M EDWARDS
HERNÁN PESSOA-MAHANA
CARLOS D PESSOA-MAHANA
ROBERTO A EBENSPERGER
author_sort GLORIA D GALARCE
title Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion
title_short Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion
title_full Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion
title_fullStr Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion
title_full_unstemmed Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion
title_sort biological evaluation of novel 6-arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of lps-induced tnf- alpha secretion
publisher BMC
series Biological Research
issn 0716-9760
0717-6287
publishDate 2008-01-01
description This study describes the effect of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as tumor necrosis factor alpha (TNF-á) production inhibitors. The newly synthesized compounds were tested for their in vitro ability to inhibit the lipolysaccharide (LPS) induced TNF-á secretion in the human promyelocytic cell line HL-60. The compound 6-Phenyl-benzimidazo [1,2-c] quinazoline, coded as Gl, resulted as the most potent inhibitor and with no significant cytotoxic activity. Thus, 6-Arylbenzimidazo [1,2-c] quinazoline derivatives may have a potential as anti-inflammatory agents
topic anti-inflammatory agents
benzimidazoquinazoline derivatives
TNF-á inhibitors
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000100006
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