What We Know and Would Like to Know about CDKL5 and Its Involvement in Epileptic Encephalopathy

What We Know and Would Like to Know about CDKL5 and Its Involvement in Epileptic Encephalopathy

In the last few years, the X-linked serine/threonine kinase cyclin-dependent kinase-like 5 (CDKL5) has been associated with early-onset epileptic encephalopathies characterized by the manifestation of intractable epilepsy within the first weeks of life, severe developmental delay, profound hypotonia...

Full description

Bibliographic Details
Main Authors:	Charlotte Kilstrup-Nielsen, Laura Rusconi, Paolo La Montanara, Dalila Ciceri, Anna Bergo, Francesco Bedogni, Nicoletta Landsberger
Format:	Article
Language:	English
Published:	Hindawi Limited 2012-01-01
Series:	Neural Plasticity
Online Access:	http://dx.doi.org/10.1155/2012/728267

Similar Items

CDKL5 and Shootin1 Interact and Concur in Regulating Neuronal Polarization.
by: Mohammad Sarfaraz Nawaz, et al.
Published: (2016-01-01)

Epileptic Encephalopathies, CDKL5 Mutations, and Infantile Spasms
by: J Gordon Millichap
Published: (2012-02-01)

CDKL5 Deficiency Disorder—A Complex Epileptic Encephalopathy
by: Martyna Jakimiec, et al.
Published: (2020-02-01)

Contagious itch: what we know and what we would like to know
by: Christina eSchut, et al.
Published: (2015-02-01)

Prostate Cancer: what we know and what we would like to know
by: Gianluigi eTaverna, et al.
Published: (2015-05-01)

Plant hormone transporters: what we know and what we would like to know
by: Jiyoung Park, et al.
Published: (2017-10-01)

Characterisation of CDKL5 Transcript Isoforms in Human and Mouse.
by: Ralph D Hector, et al.
Published: (2016-01-01)

CDKL5 localizes at the centrosome and midbody and is required for faithful cell division
by: Isabella Barbiero, et al.
Published: (2017-07-01)

Investigating emotions in Parkinson's disease: what we know and what we still don't know
by: Igor eSotgiu, et al.
Published: (2013-06-01)

Epileptic encephalopathy and atypical Rett syndrome with mutations in CDKL5: clinical and molecular characterization of two Brazilian patients
by: Erica Leitao Ermel, et al.
Published: (2013-06-01)

Microtubules: A Key to Understand and Correct Neuronal Defects in CDKL5 Deficiency Disorder?
by: Isabella Barbiero, et al.
Published: (2019-08-01)

Clinical and genetic characteristics of patients with type 2 early infantile epileptic encephalopathy caused by CDKL5 gene mutations
by: E. L. Dadali, et al.
Published: (2020-01-01)

The origin of life: what we know, what we can know and what we will never know
by: Addy Pross, et al.
Published: (2013-01-01)

Rabies : What We Know and What We Need to Know
by: Sandhu TS
Published: (2004-01-01)

MY SAY: We don't know that we don't know
by: Abd Razak, Dzulkifli
Published: (2010)

Will E-Monitoring of Policy and Program Implementation Stifle or Enhance Practice? How Would We Know?
by: Kathleen P. Conte, et al.
Published: (2018-09-01)

Are Your Athletes Progressing and How Would You Know
by: Sands, William A., et al.
Published: (2005)

What would a historian know about the future?
by: Ian Seymour Yeoman, et al.
Published: (2018-11-01)

The Natural History of Insomnia: What We Know, Don’t Know, and Need to Know
by: Michael Perlis, et al.
Published: (2011-12-01)

What do we need to know to know that animals are conscious of what they know?
by: Gary Comstock
Published: (2019-11-01)

School leadership development: what we know and how we know it
by: Ruth Jensen
Published: (2016-11-01)

What We Know about Numbers and Propositions and How We Know It
by: Scott Soames
Published: (2020-08-01)

Biodiversity: the chasm between what we know and we need to know.
by: WILLIAM E. MAGNUSSON

Besnoitiosis in caribou: What we know and what we don't know
by: Julie Ducrocq et al.
Published: (2011-09-01)

What We Should Know in Relation to What We Do Know
by: Donald L. Rice
Published: (2014-07-01)

Paediatric schistosomiasis: What we know and what we need to know.
by: Derick N M Osakunor, et al.
Published: (2018-02-01)

Interactive maps: What we know and what we need to know
by: Robert E. Roth
Published: (2013-06-01)

Ticks and Tularemia: Do We Know What We Don't Know?
by: Briana Zellner, et al.
Published: (2019-05-01)

Epigenetics in schistosomes: what we know and what we need know
by: Liu Weiwei
Published: (2016-11-01)

Vaginal Aging—What We Know and What We Do Not Know
by: Jacek K. Szymański, et al.
Published: (2021-05-01)

Metacognition in animals: how do we know that they know?
by: J. Jozefowiez, et al.
Published: (2009-01-01)

Shock after immediate TAVI implantation. Do we know what we are dealing with? How would I approach it?
by: Mariano Larman
Published: (2021-05-01)

What would the medical students like to know in laboratory medicine?
by: V Wiwanitkit
Published: (2003-06-01)

Histamine Intolerance—The More We Know the Less We Know. A Review
by: Martin Hrubisko, et al.
Published: (2021-06-01)

Pneumonia in Bhutanese children: what we know, and what we need to know
by: Sophie Jullien, et al.
Published: (2020-01-01)

Impacts of Neonicotinoids on Molluscs: What We Know and What We Need to Know
by: Endurance E Ewere, et al.
Published: (2021-01-01)

Olfaction and COVID: The little we Know and what else we need to know
by: Fábio de Rezende Pinna, et al.
Published: (2020-06-01)

Microbiome in Multiple Sclerosis; Where Are We, What We Know and Do Not Know
by: Marina Kleopatra Boziki, et al.
Published: (2020-04-01)

Asthma in the elderly: what we know and what we have yet to know
by: Anahí Yáñez, et al.
Published: (2014-01-01)

What we know and what we don't know about preventing stroke.
by: Druin Burch, et al.
Published: (2014-04-01)