T lymphocytes from chagasic patients are activated but lack proliferative capacity and down-regulate CD28 and CD3ζ.

T lymphocytes from chagasic patients are activated but lack proliferative capacity and down-regulate CD28 and CD3ζ.

BACKGROUND: Chronic persistent infections have been associated with T lymphocytes functional impairment. The aim of this study was to compare the activation status, the proliferative potential and the expression of CD28 and CD3ζ chain on T lymphocytes between chronic chagasic patients and uninfected...

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Bibliographic Details
Main Authors: Nicolás A Giraldo, Natalia I Bolaños, Adriana Cuellar, Nubia Roa, Zulma Cucunubá, Fernando Rosas, Víctor Velasco, Concepción J Puerta, John M González
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3561132?pdf=render

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http://europepmc.org/articles/PMC3561132?pdf=render

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