Role of mTOR-Regulated Autophagy in Synaptic Plasticity Related Proteins Downregulation and the Reference Memory Deficits Induced by Anesthesia/Surgery in Aged Mice

Role of mTOR-Regulated Autophagy in Synaptic Plasticity Related Proteins Downregulation and the Reference Memory Deficits Induced by Anesthesia/Surgery in Aged Mice

Postoperative cognitive dysfunction increases mortality and morbidity in perioperative patients and has become a major concern for patients and caregivers. Previous studies demonstrated that synaptic plasticity is closely related to cognitive function, anesthesia and surgery inhibit synaptic functio...

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Bibliographic Details
Main Authors: Sunan Gao, Siyu Zhang, Hongmei Zhou, Xiaoyan Tao, Yunjian Ni, Daqing Pei, Shuai Kang, Weiwei Yan, Jian Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Aging Neuroscience
Subjects:
rapamycin
mTOR
postoperative cognitive dysfunction
aged
synaptic plasticity
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.628541/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2021.628541/full

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