NCOA4 Deficiency Impairs Systemic Iron Homeostasis

NCOA4 Deficiency Impairs Systemic Iron Homeostasis

The cargo receptor NCOA4 mediates autophagic ferritin degradation. Here we show that NCOA4 deficiency in a knockout mouse model causes iron accumulation in the liver and spleen, increased levels of transferrin saturation, serum ferritin, and liver hepcidin, and decreased levels of duodenal ferroport...

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Bibliographic Details
Main Authors: Roberto Bellelli, Giorgia Federico, Alessandro Matte’, David Colecchia, Achille Iolascon, Mario Chiariello, Massimo Santoro, Lucia De Franceschi, Francesca Carlomagno
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Cell Reports
Subjects:
iron
hypochromic anemia
NCOA4
ferritin
autophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715015065

Internet

http://www.sciencedirect.com/science/article/pii/S2211124715015065

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