Small Molecule Inhibitor C188-9 Synergistically Enhances the Demethylated Activity of Low-Dose 5-Aza-2′-Deoxycytidine Against Pancreatic Cancer

Small Molecule Inhibitor C188-9 Synergistically Enhances the Demethylated Activity of Low-Dose 5-Aza-2′-Deoxycytidine Against Pancreatic Cancer

Aberrant DNA methylation, especially hypermethylation of tumor suppressor genes, has been associated with many cancers' progression. 5-Aza-2′-deoxycytidine (DAC) can reverse hypermethylation-induced gene silencing via regulating DNA methyltransferases (DNMTs) activity, In addition, low-dose of...

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Bibliographic Details
Main Authors: Rui Kong, Guangming Sun, Xina Li, Linfeng Wu, Le Li, Yilong Li, Fei Wang, Ping Xuan, Shifeng Yang, Bei Sun, Jisheng Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Oncology
Subjects:
5-aza-2′-deoxycytidine
C188-9
STAT3
RASSF1A
DNA methylation
epithelial-to-mesenchymal transition
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00612/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00612/full

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