Exosomal Expression of CXCR4 Targets Cardioprotective Vesicles to Myocardial Infarction and Improves Outcome after Systemic Administration

Exosomal Expression of CXCR4 Targets Cardioprotective Vesicles to Myocardial Infarction and Improves Outcome after Systemic Administration

Cell therapy has been evaluated to enhance heart function after injury. Delivered cells mostly act via paracrine mechanisms, including secreted growth factors, cytokines, and vesicles, such as exosomes (Exo). Intramyocardial injection of cardiac-resident progenitor cells (CPC)-derived Exo reduced sc...

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Bibliographic Details
Main Authors: Alessandra Ciullo, Vanessa Biemmi, Giuseppina Milano, Sara Bolis, Elisabetta Cervio, Emanuel Tudor Fertig, Mihaela Gherghiceanu, Tiziano Moccetti, Giovanni G. Camici, Giuseppe Vassalli, Lucio Barile
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:International Journal of Molecular Sciences
Subjects:
exosomes
CXCR4
cardiac progenitor cells
intravenous injection
Online Access:https://www.mdpi.com/1422-0067/20/3/468

Internet

https://www.mdpi.com/1422-0067/20/3/468

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