High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring

High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring

Objectives: Chronic and high consumption of fat constitutes an environmental stress that leads to metabolic diseases. We hypothesized that high-fat diet (HFD) transgenerationally remodels the epigenome of spermatozoa and metabolism of the offspring. Methods: F0-male rats fed either HFD or chow diet...

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Bibliographic Details
Main Authors: Thais de Castro Barbosa, Lars R. Ingerslev, Petter S. Alm, Soetkin Versteyhe, Julie Massart, Morten Rasmussen, Ida Donkin, Rasmus Sjögren, Jonathan M. Mudry, Laurène Vetterli, Shashank Gupta, Anna Krook, Juleen R. Zierath, Romain Barrès
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S221287781500232X

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http://www.sciencedirect.com/science/article/pii/S221287781500232X

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