Regulator of G-Protein Signaling (RGS) Protein Modulation of Opioid Receptor Signaling as a Potential Target for Pain Management

Regulator of G-Protein Signaling (RGS) Protein Modulation of Opioid Receptor Signaling as a Potential Target for Pain Management

Opioid drugs are the gold standard for the management of pain, but their use is severely limited by dangerous and unpleasant side effects. All clinically available opioid analgesics bind to and activate the mu-opioid receptor (MOR), a heterotrimeric G-protein-coupled receptor, to produce analgesia....

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Bibliographic Details
Main Authors: Nicolas B. Senese, Ram Kandasamy, Kelsey E. Kochan, John R. Traynor
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
analgesia
G-proteins
opioid receptors
pain
RGS proteins
signaling
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2020.00005/full

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https://www.frontiersin.org/article/10.3389/fnmol.2020.00005/full

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