Quantification of intrinsic subtype ambiguity in Luminal A breast cancer and its relationship to clinical outcomes

Quantification of intrinsic subtype ambiguity in Luminal A breast cancer and its relationship to clinical outcomes

Abstract Background PAM50 gene profiling assigns each cancer to a single intrinsic subtype. However, individual cancers vary in their adherence to a prototype, and due to bulk tissue sampling, some may exhibit expression patterns that indicate intra-tumor admixture of multiple subtypes. Our objectiv...

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Bibliographic Details
Main Authors: Neeraj Kumar, Dan Zhao, Dulal Bhaumik, Amit Sethi, Peter H. Gann
Format: Article
Language:English
Published: BMC 2019-03-01
Series:BMC Cancer
Subjects:
Intrinsic subtype
Intratumor heterogeneity
PAM50
Luminal a
Online Access:http://link.springer.com/article/10.1186/s12885-019-5392-z

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http://link.springer.com/article/10.1186/s12885-019-5392-z

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