Single cell RNA-seq reveals profound transcriptional similarity between Barrett’s oesophagus and oesophageal submucosal glands

Single cell RNA-seq reveals profound transcriptional similarity between Barrett’s oesophagus and oesophageal submucosal glands

Barrett’s oesophagus is associated with an increased risk of oseophageal cancer, but its cell of origin is unclear. Here the authors show, using single-cell RNA sequencing of biopsies from six patients and two unaffected subjects, that cells in Barrett’s oesophagus show a transcriptional profile tha...

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Bibliographic Details
Main Authors: Richard Peter Owen, Michael Joseph White, David Tyler Severson, Barbara Braden, Adam Bailey, Robert Goldin, Lai Mun Wang, Carlos Ruiz-Puig, Nicholas David Maynard, Angie Green, Paolo Piazza, David Buck, Mark Ross Middleton, Chris Paul Ponting, Benjamin Schuster-Böckler, Xin Lu
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06796-9

Internet

https://doi.org/10.1038/s41467-018-06796-9

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