Clinical Validation of a Multiplex Kit for RAS Mutations in Colorectal Cancer: Results of the RASKET (RAS KEy Testing) Prospective, Multicenter Study

Clinical Validation of a Multiplex Kit for RAS Mutations in Colorectal Cancer: Results of the RASKET (RAS KEy Testing) Prospective, Multicenter Study

Background: RAS (KRAS and NRAS) testing is required to predict anti-epidermal growth factor receptor (EGFR) treatment efficacy in metastatic colorectal cancer (CRC). Although direct sequencing (DS) with manual microdissection (MMD) is widely used, a diagnostic kit providing rapid detections of RAS m...

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Bibliographic Details
Main Authors: Takayuki Yoshino, Kei Muro, Kensei Yamaguchi, Tomohiro Nishina, Tadamichi Denda, Toshihiro Kudo, Wataru Okamoto, Hiroya Taniguchi, Kiwamu Akagi, Takeshi Kajiwara, Shuichi Hironaka, Taroh Satoh
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:EBioMedicine
Subjects:
Colorectal cancer
RAS mutation
Anti-EGFR antibody treatment
Biomarker
In vitro diagnostics
RASKET study
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415000559

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http://www.sciencedirect.com/science/article/pii/S2352396415000559

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