The p90 ribosomal S6 kinase (RSK) is a mediator of smooth muscle contractility.

In the canonical model of smooth muscle (SM) contraction, the contractile force is generated by phosphorylation of the myosin regulatory light chain (RLC20) by the myosin light chain kinase (MLCK). Moreover, phosphorylation of the myosin targeting subunit (MYPT1) of the RLC20 phosphatase (MLCP) by t...

Full description

Bibliographic Details
Main Authors: Mykhaylo Artamonov, Ko Momotani, Darkhan Utepbergenov, Aaron Franke, Alexander Khromov, Zygmunt S Derewenda, Avril V Somlyo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3596281?pdf=render