Marburg virus evades interferon responses by a mechanism distinct from ebola virus.

Marburg virus evades interferon responses by a mechanism distinct from ebola virus.

Previous studies have demonstrated that Marburg viruses (MARV) and Ebola viruses (EBOV) inhibit interferon (IFN)-alpha/beta signaling but utilize different mechanisms. EBOV inhibits IFN signaling via its VP24 protein which blocks the nuclear accumulation of tyrosine phosphorylated STAT1. In contrast...

Full description

Bibliographic Details
Main Authors: Charalampos Valmas, Melanie N Grosch, Michael Schümann, Judith Olejnik, Osvaldo Martinez, Sonja M Best, Verena Krähling, Christopher F Basler, Elke Mühlberger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2799553?pdf=render

Internet

http://europepmc.org/articles/PMC2799553?pdf=render

Similar Items